I am working on putting together brief overviews about the different Fragile X Associated Disorders - and this is the second (behind the Fragile X Syndrome page I have up). You can find this post as well under the tab at the top labeled FXPOI. Much of this is simplified to make it easier to understand, and while I got my information from Fragile X websites - it should not be taken as medical advice.
Fragile X Associated Primary Ovarian Insufficiency, or FXPOI is a condition in which the ovaries stop functioning normally in a woman younger than age 40. Common symptoms of POI include absent or irregular periods and infertility. POI is not menopause. Women with FXPOI may develop symptoms similar to those of menopause such as hot flashes and vaginal dryness, but it differs from menopause in some important ways.
- Women with POI are still able to get pregnant in some cases because their ovaries may release viable eggs now and then.
- Women with POI can experience a return of menstrual periods
- Some women will become pregnant years after an initial diagnosis.
ALL women that are carriers of FXS have some decrease in ovarian function (decreased fertility), and some are at risk for anxiety and depression as well. It must be noted though, that many women with premutations are able to conceive and you should not assume decreased fertility. The decreased fertility is related to increased levels of some hormones, particularly FSH and a decreased length of a phase in the menstrual cycle called the follicular phase. The current recommendation for women with the premutation is to have FSH levels evaluated and monitored throughout their childbearing years.